Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Primary TargetAXOR12 and hOT7T175

Target K_i: 42 pM for AXOR12 and hOT7T175

General description

A decapeptide with C-terminally amidated LRF-motif that acts as a potent and selective agonist of AXOR12 and hOT7T175 (a novel human G-protein-coupled receptor). More potent than the parent peptide. Induces an increase in intracellular Ca²⁺ levels in CHO/h175 and CHO/AXOR12:Gqi5 cells and exhibits about 8-fold higher receptor binding affinity (K_i = 42 pM, determined by competitive binding analysis) as compared to Metastin (Cat. No. 444885).

A decapeptide with C-terminally amidated LRF-motif that acts as a potent and selective agonist of AXOR12 and hOT7T175 (a novel human G-protein-coupled receptors). Induces an increase in intracellular Ca²⁺ levels in CHO/h175 and CHO/AXOR12:Gqi5 cells and exhibits about 8-fold higher receptor binding affinity (K_i = 42 pM) compared to Metastin (Cat. No. 445885).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Kotani, M., et al. 2001. J. Biol. Chem.276, 34631.Ohtaki, T., et al. 2001. Nature411, 613.Muir, A.I., et al. 2001. J. Biol. Chem.276, 28969.

Packaging

1 mg in Plastic ampoule

Packaged under inert gas

Sequence

H-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂

Warning

Toxicity: Standard Handling (A)